PHENOMES:
The main objective of the project is to develop new bioinformatics tools to facilitate interpretation of metabolomics data from in vivo experiments at the pre-clinical or clinical level. Specifically, we aim at developing tools to resolve the complex lipidomics profile data at the biofluid or tissue level, and enable interpretation of such data in the context of other experimental evidence and available knowledge.
Related projects: TRANSCENDO, VISUBIOMED
Latest news and relevant publications
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M. Orešič, V. Hänninen, A. Vidal-Puig, Lipidomics: a new window to biomedical frontiers, Trends Biotechnol. 26(12), 647-652 (2008).
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T. Karpanen, M. Bry, H. M. Ollila, T. Seppänen-Laakso, E. Liimatta, H. Leskinen, R. Kivelä, T. Helkamaa, M. Merentie, M. Jeltsch, K. Paavonen, L. C. Andersson, E. Mervaala, I. E. Hassinen, S. Ylä-Herttuala, M. Orešič, K. Alitalo, Overexpression of VEGF-B in mouse heart alters cardiac lipid metabolism and induces myocardial hypertrophy, Circ. Res. 103(9), 1018-1026 (2008). Editorial
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T. K. Pilvi, T. Seppänen-Laakso, H. Simolin, P. Finckenberg, A. Huotari, K. H. Herzig, R. Korpela, M. Orešič, E. M. Mervaala, Metabolomic changes in fatty liver can be modified by dietary protein and calcium during energy restriction, World J. Gastroenterol. 14 (28), 4462-4472 (2008).
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K. Minehira, S. G. Young, C. J. Villanueva, L. Yetukuri, M. Orešič, M. K. Hellerstein, R. V. Farese Jr., J. D. Horton, F. Preitner, B. Thorens, L. Tappy, Blocking VLDL secretion causes hepatic steatosis but does not affect peripheral lipid stores or insulin sensitivity in mice, J. Lipid Res. 49(9), 2038-2044 (2008).
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L. Yetukuri, K. Ekroos, A. Vidal-Puig, M. Orešič, Informatics and computational strategies for the study of lipids, Mol. BioSyst. 4, 121-127 (2008).
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G. Medina-Gomez, S. Gray, L. Yetukuri, K. Shimomura, M. Campbell, K. Curtis, S. Virtue, M. Jimenez-Linan, M. Blount, G. Yeo, M. Lopez, T. Seppänen-Laakso, F. M. Ashcroft, M. Orešič, and A. Vidal-Puig, PPAR gamma 2 prevents lipotoxicity by controlling adipose tissue expandability and peripheral lipid metabolism, PLoS Genet. 3: e64 (2007).
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L. Yetukuri, M. Katajamaa, G. Medina-Gomez, T. Seppänen-Laakso, A. Vidal Puig, and M. Orešič, Bioinformatics strategies for lipidomics analysis: characterization of obesity related hepatic steatosis, BMC Systems Biology 1, e12 (2007).
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M. Orešič, A. Vidal-Puig, and V. Hänninen, Metabolomic approaches to phenotype characterization and applications to complex diseases, Expert Rev. Mol. Diagn. 6, 575-585 (2006).
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P.V. Gopalacharyulu, E. Lindfors, C. Bounsaythip, T. Kivioja, L. Yetukuri, J. Hollmén, and M. Orešič, Data integration and visualization system for enabling conceptual biology, Bioinformatics 21, i177-i185 (2005).